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2 edition of Radiation-induced chromosome aberrations in human cells. found in the catalog.

Radiation-induced chromosome aberrations in human cells.

Jakob Visfeldt

Radiation-induced chromosome aberrations in human cells.

by Jakob Visfeldt

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Published by Danish Atomic Energy Commission, Research Establishment Riso in Roskilde .
Written in English


Edition Notes

SeriesRiso report / Danish Atomic Energy Commission, Research Establishment Riso -- no.117
ID Numbers
Open LibraryOL13778212M

/ Loucas BD [and others] --G2 chromatid damage and repair kinetics in normal human fibroblast cells exposed to low- or high-LET radiation / Kawata T [and others] --Cytogenetic effects of densely ionising radiation in human lymphocytes: impact of cell cycle delays / Nasonova E, Ritter S --Chromosome aberrations induced by high-LET carbon ions. Chatterjee, A. A Model for Interphase Chromosomes and Evaluation of Radiation-Induced Aberrations. Radiat. Res. , – (). We have developed a theoretical model for evaluating ra-diation-induced chromosomal exchanges by explicitly tak-ing into account interphase (G0/G1) chromosome structure, nuclear organization of chromosomes, the.

Methods: The bi-exponential repair kinetics model is implemented into a recent simulation code called RITCARD (Radiation Induced Tracks, Chromosome Aberrations, Repair, and Damage). RITCARD simulates the geometric configuration of human chromosomes, radiation-induced breaks, their repair, and the creation of various categories of : Ianik Plante, Tony Slaba, Zarana Shavers, Megumi Hada.   Homogeneous sensitivity of human peripheral blood lymphocytes to radiation-induced chromosome damage that there is no difference in aberration frequency in first-division cells sampled at Cited by:

Cornforth, M.N. () Radiation-induced damage and the formation of chromosomal aberrations. In: DNA damage and repair, J.A. Nickoloff and M.F. Hoekstra eds. (Totowa, N.J., Humana Press), Pinkel, D. et al. () Fluorescence in situ hybridizaton with human chromosome-specific libraries: Detection of trisomy 21 and translocations of chromosome 4. Subsequent cytogenetic studies showed that Trp53 +/− mice were highly prone to radiation-induced whole chromosome loss and gain (aneuploidy), and that the molecular data on tumorigenesis could be explained by radiation-induced loss of the whole chromosome (chr11) bearing wt Trp53, with duplication of the copy bearing mTrp53 being necessary to.


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Radiation-induced chromosome aberrations in human cells by Jakob Visfeldt Download PDF EPUB FB2

Another investigation on X-ray induced chromosome aberrations in human euploid cells grown in vitro has been published by Chu et al. Their cell cul­ tures were derived from surgical material from a variety of tissues. The morphology of the cultured cells was in most instances fibroblast-like.

Three acute doses were used, i.e. 25, 50 and r, and the chromosome aberrations Cited by: 6. Radiation-induced chromosome aberrations in human cells. Roskilde, Danish Atomic Energy Commission Research Establishment Risö, (OCoLC) Online version: Visfeldt, Jakob.

Radiation-induced chromosome aberrations in human cells. Roskilde, Danish Atomic Energy Commission Research Establishment Risö, (OCoLC) Material Type.

Introduction The dependence of the yield of chromosome aberrations in human lymphocytes, especially of dicentrics and rings, upon the dose of X- and y-rays has been extensively studied by a number of authors since [,17,23, 24,26,28,31,34].Cited by:   One of these breakage prone regions is the paracentric heterochromatin of chromosome 1, band 1q This band is commonly involved in chromosomal aberrations occurring in a wide range of human haematological and Radiation-induced chromosome aberrations in human cells.

book malignancies (Atkin, ; Olah et Cited by: Enzymatic misrepair of ionizing-radiation-induced DNA damage can produce large-scale rearrangements of the genome, such as translocations and dicentrics.

These and other chromosome exchange aberrations can cause major phenotypic alterations, including cell death, mutation and neoplasia. RADIATION-INDUCED CHROMOSOME ABERRATIONS IN MAN: A POSSIBLE BIOLOGICAL DOSIMETER.

Technical Report. RADIATION-INDUCED CHROMOSOME ABERRATIONS IN HUMAN LEUKOCYTES IN VITRO, RADIOSENSITIVITY OF CHROMOSOMES, AND THE DOSE-EFFECT RELATIONSHIP. (in Russian) Journal Article - Genetika, No. 7, (July. Radiation-induced chromosome aberrations, particularly exchange-type aberrations, are thought to result from misrepair of DNA double-strand breaks.

The relationship between individual pathways of break repair and aberration formation is not by: Human whole blood samples were irradiated with a constant dose of either kV X-rays or Cs γ-rays for various periods of time. The yields of chromosome aberrations showed a striking dependence on the dose by: The in vitro chromosomal aberration test may employ cultures of established cell lines, cell strains or primary cell cultures.

Chromosomal aberrations are the cause of many human. The total radiation dose received by a somatic or genetic cell and the dose rate determine the: a. cell growth reduction rate b.

Cause of chromosome aberrations c. Mechanism of action of ionizing radiation on biologic macromolecules d. Production of chromosome aberrations. Radiation induced chromosome aberrations and the poisson distribution. Summary. Data on the distribution of dicentrics and acentrics observed when human lymphocytes are cultured for 48 h after irradiation by X-rays,γ-rays, and neutrons Cited by: Abstract.

In his classical paper “Chromosome Aberrations Induced by X-rays” inSax measured (among other things) break and exchange-point frequencies along Tradescantia chromosome arms. He found these frequencies appreciably higher in the proximal compared to the distal one-third of the arms, and concluded that “ chromosome break or exchange points Cited by: In order to find an explanation for the eventual disappearance of all chromosome aberrations in two radiosensitive human tumour cell lines, the type and stability of different aberration types was investigated in more detail.

To classify the aberrations into unstable and stable types, threecolour fluorescence in situ hybridization was performed, including a whole-chromosome Cited by: 8. The incidence of chromosome aberrations in peripheral blood lymphocytes of dockyard workers has been followed over a yr period.

These workers were exposed to mixed neutronγ radiation Cited by: Aneuploid frequency of chromosomes 1 and 4 increased with radiation doses, and a significantly higher frequency of aneuploidy was observed in the surviving cells analyzed at h compared to 28 h. These results indicate that low-dose of X-irradiation can induce delayed aneuploidy of chromosomes 1 and 4 in normal by: 6.

Radiation-induced chromosomal aberrations represent an early marker of late effects, including cell killing and transformation. The measurement of cytogenetic damage in tissues, generally in blood lymphocytes, from patients treated with radiotherapy has been studied for many years to predict individual sensitivity and late morbidity.

This book comprises a collection of chapters describing topics from traditional radiation cytogenetic analysis methods to the modern fluorescence based-analysis and high throughput automatic analysis methods, for radiation-induced DNA damage in cells.

Simulating the scoring system (such as mFISH) used in the experiment then gives the observable aberration pattern for that simulated cell; a simple example might be that the cell contains just one dicentric, involving chromosomes 4 and X.

Iterating, thousands or millions of individual cells are simulated one by one. of complex aberrations (see Fig. 2 and Fig. 3e and f). HR, the most accurate process, depends on the Rad52 and Rad51 proteins and occurs usually between ex-tended regions of sequence homology located on sister chromatids in cells undergoing mitotic cell cycles or on homologous chromatids in cells undergoing mei-otic cell cycles.

Abstract. Long-term exposure to low doses of ionizing radiation may affect cells and tissues and result in Various adverse health effects.

The purpose of this study was to investigate whether chromosome aberrations and haematological alterations could be used as biomarkers of possible radiation injury in workers exposed to ionizing by:. Start studying Radiation biology ch. Learn vocabulary, terms, and more with flashcards, games, and other study tools.

Radiation induced chromosome aberrations single hit: Linear non-threshold. Which cells are involved in the human immune response.Historically, chromosome aberrations are scored at the first metaphase after exposure to radiation.

Therefore, depending on when in cell cycle the damage happens, there are two types of aberrations Chromosome aberrations - both sister chromatid strands are damage: >/cell.Prime examples of inevitably lethal aberrations: Ring chromosome Dicentric chromosomes Anaphase bridge (chromatid aberration) Prime examples of chromosomal aberrations, potentially non-lethal: Symmetric translocations; Small deletions Note that all of these radiation-induced aberrations require two double-stranded DNA breaks.